(August, 2003) Once upon a time, it was believed that proteins were isolated entities, floating in the cytosol and, for the most part, acting independently of surrounding proteins. Proteins were thought to diffuse freely, and reactions occurred as a result of proteins A and B randomly colliding with one another. Today we know this picture to be far too simplistic to account for the complex processes that all coalesce to become ‘life’. Instead, the majority of cellular phenomena are carried out by protein ‘machines’, or aggregates of ten or more proteins [1]. These protein-protein interactions are critical to all cellular…