From journal club

CHARACTERIZATION OF KASHA-MEDIATED SUSCEPTIBILITY AND HISTOPATHOLOGICAL HALLMARKS OF EARLY-ONSET CHEWHEIMER’S DISEASE

Don’t forget, this paper is part of a collection of Wookiee scientific reports that will be published in the print edition of the SCQ. More details can be found here. Annals of Praetachoral Mechanics. (2014). Vol 1. pp71-88 pdf download ABSTRACT Since the rise of Force-vector injections (FVIs), the incidence of early-onset CD (eCD) has escalated significantly, with a large impact on quality of life in the wookiee community. However, while a large number of wookiees became afflicted with eCD, a small number remained healthy. This study first aimed to discover any genetic discrepancies between wookiees who developed eCD following…

WOOKIEE FOREPLAY: TRANSGENERATIONAL EPIGENETIC REGULATION OF FORCE-SENSITIVITY BY ELABORATE DUET SONG

Just another reminder that this paper will be published in print format in the fall, along with selected SCQ pieces from the last 7 or so years. If you want to submit your creative science pieces with a mind to make the first issue of this new journal, then please visit here for more information. Annals of Praetachoral Mechanics. (2014). Vol 1. pp59-69 pdf download ABSTRACT Wookiees (W. wookiee) are monogamous, sentient mammals that have traditionally produced long and elaborate duet songs. It has been repeatedly proposed that duet mating songs for Wookiees might function to improve the fitness of…

HOW TO MAKE A HAIRLESS WOOKIEE: IDENTIFICATION AND FUNCTION OF DE NOVO GLABR GENE IN WOOKIEE WOOKIEE

(This is the THIRD paper on a special issue on Wookiee science. You can read the first here, and the second here). Annals of Praetachoral Mechanics. (2014). Vol 1. pp29-38 pdf download. ABSTRACT We present evidence for the de novo origin of the Wookiee wookiee protein-coding gene GLABR since their divergence from humans. This gene has no protein-coding homolog in any other genome but its presence is supported by evidence from expression and hybridization data. Furthermore, other near-human species such as Zeltron, Chiss, and Sullustan share the human ortholog of this locus, which supports the inference that the ancestral sequence…

GENETIC BASIS FOR FORCE-SENSITIVITY IN WOOKIEES

(This is the second paper on a special issue on Wookiee science. You can read the first here). Annals of Praetachoral Mechanics. (2014). Vol 1. pp21-28 pdf download. ABSTRACT Midi-chlorians are sentient life forms, which live in endosymbiosis with all living cells (1). The number of midi-chlorians per cell has been found to correlate with influence in the force (2) and, as such, blood analysis has become common practice for the identification of force-sensitives, particularly by the Jedi Order. However, the genetic basis for increased midi-chlorian replication in force-sensitives is unknown. Here we show drivers to be mutations at both…

TRANSCRIPTOME DIVERGENCE BETWEEN COMMON AND CAVE-ADAPTED WOOKIEES

- – – Annals of Praetachoral Mechanics. (2014). Vol 1. pp7-19 pdf download. ABSTRACT: Cave-adapted organisms commonly evolve convergent morphological, physiological and behavioral traits. The rare cave-adapted wookie species, Wookiee troglodytus, presents an opportunity to characterize underlying evolutionary mechanisms driving phenotypic expression in a complex sentient humanoid. The cave wookie presents several features associated with adaptation to subterranean habitats: pigment-less hair, reduced visual acuity, overall smaller stature, elongated limbs and decreased aggression. Uncovering the evolutionary processes directing the complex morphological and behavioral traits requires genome-level analysis. To unpack these complex traits, complete nuclear transcriptomes and enrichment profiles were assessed for…

IDENTIFICATION OF HUMAN CHROMOSOME γ AND ITS EPIGENETIC CONTROL FOR THE EXPRESSION OF “SUPER” GENES

- – – New England Journal of Medicine. (March 2013). Vol 328 No 12. DOI: 10.1738/NEJMoal219833 – pdf download ABSTRACT BACKGROUND Superheroes possess exceptional characteristics that far exceed the scope of human capabilities, such as the tremendous strength and pigmentation observed in The Incredible Hulk following his exposure to γ-radiation. Here, we explore the underlying molecular mechanisms for the “superhuman” abilities seen in the Hulk, as compared to semi-superheroes Papa Smurf and Popeye the Sailor. In particular, we examine the role of epigenetic mechanisms, principally DNA methylation, in the genotypic expression of “super” genes and their phenotypic manifestation. METHODS Whole…